diff --git a/dlls/kernelbase/registry.c b/dlls/kernelbase/registry.c
index f8afb94f8d2..d1588d0b265 100644
--- a/dlls/kernelbase/registry.c
+++ b/dlls/kernelbase/registry.c
@@ -1699,13 +1699,22 @@ LSTATUS WINAPI RegGetValueW( HKEY hKey, LPCWSTR pszSubKey, LPCWSTR pszValue,
 
     if (pvData && !pcbData)
         return ERROR_INVALID_PARAMETER;
+
     if ((dwFlags & RRF_RT_REG_EXPAND_SZ) && !(dwFlags & RRF_NOEXPAND) &&
             ((dwFlags & RRF_RT_ANY) != RRF_RT_ANY))
         return ERROR_INVALID_PARAMETER;
 
+    if ((dwFlags & RRF_WOW64_MASK) == RRF_WOW64_MASK)
+        return ERROR_INVALID_PARAMETER;
+
     if (pszSubKey && pszSubKey[0])
     {
-        ret = RegOpenKeyExW(hKey, pszSubKey, 0, KEY_QUERY_VALUE, &hKey);
+        REGSAM samDesired = KEY_QUERY_VALUE;
+
+        if (dwFlags & RRF_WOW64_MASK)
+            samDesired |= (dwFlags & RRF_SUBKEY_WOW6432KEY) ? KEY_WOW64_32KEY : KEY_WOW64_64KEY;
+
+        ret = RegOpenKeyExW(hKey, pszSubKey, 0, samDesired, &hKey);
         if (ret != ERROR_SUCCESS) return ret;
     }
 
@@ -1795,13 +1804,22 @@ LSTATUS WINAPI RegGetValueA( HKEY hKey, LPCSTR pszSubKey, LPCSTR pszValue,
 
     if (pvData && !pcbData)
         return ERROR_INVALID_PARAMETER;
+
     if ((dwFlags & RRF_RT_REG_EXPAND_SZ) && !(dwFlags & RRF_NOEXPAND) &&
             ((dwFlags & RRF_RT_ANY) != RRF_RT_ANY))
         return ERROR_INVALID_PARAMETER;
 
+    if ((dwFlags & RRF_WOW64_MASK) == RRF_WOW64_MASK)
+        return ERROR_INVALID_PARAMETER;
+
     if (pszSubKey && pszSubKey[0])
     {
-        ret = RegOpenKeyExA(hKey, pszSubKey, 0, KEY_QUERY_VALUE, &hKey);
+        REGSAM samDesired = KEY_QUERY_VALUE;
+
+        if (dwFlags & RRF_WOW64_MASK)
+            samDesired |= (dwFlags & RRF_SUBKEY_WOW6432KEY) ? KEY_WOW64_32KEY : KEY_WOW64_64KEY;
+
+        ret = RegOpenKeyExA(hKey, pszSubKey, 0, samDesired, &hKey);
         if (ret != ERROR_SUCCESS) return ret;
     }
 
diff --git a/include/winreg.h b/include/winreg.h
index c00379150a6..00bc8c02dc8 100644
--- a/include/winreg.h
+++ b/include/winreg.h
@@ -81,6 +81,9 @@ typedef LONG LSTATUS;
 #define RRF_RT_DWORD            (RRF_RT_REG_BINARY | RRF_RT_REG_DWORD)
 #define RRF_RT_QWORD            (RRF_RT_REG_BINARY | RRF_RT_REG_QWORD)
 #define RRF_RT_ANY              0xffff
+#define RRF_SUBKEY_WOW6464KEY   (1 << 16)
+#define RRF_SUBKEY_WOW6432KEY   (1 << 17)
+#define RRF_WOW64_MASK          (RRF_SUBKEY_WOW6432KEY | RRF_SUBKEY_WOW6464KEY)
 #define RRF_NOEXPAND            (1 << 28)
 #define RRF_ZEROONFAILURE       (1 << 29)