diff --git a/Make.rules.in b/Make.rules.in
index 77cf55800d8..0f9c02a6f5e 100644
--- a/Make.rules.in
+++ b/Make.rules.in
@@ -143,7 +143,7 @@ filter: dummy
 	$(CC) -c $(ALLCFLAGS) -o $@ $<
 
 .c.cross.o:
-	$(CROSSCC) -c $(INCLUDES) $(DEFS) $(CPPFLAGS) $(CFLAGS) -o $@ $<
+	$(CROSSCC) -c $(INCLUDES) $(DEFS) -DWINE_CROSSTEST $(CPPFLAGS) $(CFLAGS) -o $@ $<
 
 .y.tab.c:
 	$(BISON) $(BISONFLAGS) -p $*_ -o $@ $<
diff --git a/configure.ac b/configure.ac
index 7d9031d283b..f39347ed1c9 100644
--- a/configure.ac
+++ b/configure.ac
@@ -2160,7 +2160,9 @@ esac
 
 dnl **** Generate output files ****
 
-AH_TOP([#define __WINE_CONFIG_H])
+AH_TOP([#ifndef WINE_CROSSTEST
+#define __WINE_CONFIG_H])
+AH_BOTTOM([#endif /* WINE_CROSSTEST */])
 
 AC_CONFIG_COMMANDS([include/stamp-h], [echo timestamp > include/stamp-h])
 
diff --git a/include/config.h.in b/include/config.h.in
index 29e711c90e0..0faf127db60 100644
--- a/include/config.h.in
+++ b/include/config.h.in
@@ -1,5 +1,6 @@
 /* include/config.h.in.  Generated from configure.ac by autoheader.  */
 
+#ifndef WINE_CROSSTEST
 #define __WINE_CONFIG_H
 
 /* Define to a function attribute for Microsoft hotpatch assembly prefix. */
@@ -1307,3 +1308,5 @@
 #ifndef __cplusplus
 #undef inline
 #endif
+
+#endif /* WINE_CROSSTEST */